Dubious consent aside (because I could argue that but -- hrmg; why bother? It could be argued that as House's prescribing physician, if House and Wilson entered into a romantic relationship, Wilson could be charge with sexual abuse against House. Would that be true? Of course not! But anyway), there is no evidence that the sex was mentally damaging either because of lack of canon evidence. In fact, all canon evidence that is available points to Wilson and Grace having an emotionally satisfying relationship.